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Getting CDONTS to work on Windows Server 2008 x64

1) Copy CDONTS.dll from another server to C:\Windows\SysWOW64

2) Run regsvr32 c:\windows\SysWOW64\cdonts.dll

3) Grant the appropriate permissions on C:\inetpub\mailroot\pickup (I granted USERS group Modify permissions).  You could get permission denied if the folder security isn’t adjusted.

4) I’m assuming you have installed the SMTP Service located in Server Manager > Features > SMTP Server option

5) Make sure when you when you install the SMTP service, you enable Relay for localhost > Administrative Tools > Internet Information Services (IIS6) > SMTP Virtual Server > Right click, Properties > Access Tab > Relay button > Add 127.0.0.1 in the option.   Also enable logging for additional troubleshooting.

Reference

http://weblogs.asp.net/steveschofield/archive/2008/08/18/getting-cdonts-to-work-on-windows-server-2008-x64.aspx

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